MIPS-21335

• UNSPSC Description:

  MIPS-21335 is an PI3KC2α inhibitor (IC50: 7 nM). MIPS-21335 also inhibits PI3KC2β, p110α, p110β and p110δ (IC50: 0.043, 0.140, 0.386, 0.742 μM). MIPS-21335 has antithrombotic effect[1].

• Target Antigen:

  PI3K

• Type:

  Reference compound

• Related Pathways:

  PI3K/Akt/mTOR

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/mips-21335.html

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  COC1=C2N=C(N3CCN=C3C2=CC=C1OCC4=CC([N+]([O-])=O)=CC=C4)NC(C5=CN=C(C=C5)N)=O

• Molecular Weight:

  487.47

• References & Citations:

  [1]Selvadurai MV, et al. Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation. Sci Transl Med. 2020 Jul 22;12(553):eaar8430.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2569296-51-9