TCS PIM-1 1

TCS PIM-1 1

• CAS Number: 491871-58-0
• UNSPSC Description: TCS PIM-1 1 (SC 204330) is a potent, selective and ATP-competitive Pim-1 kianse inhibitor with an IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2 (IC50s >20000 nM)[1].
• Target Antigen: Pim
• Type: Reference compound
• Related Pathways: JAK/STAT Signaling
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/TCS-PIM-1-1.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: OC1=C(C(N2)=CC(C3=CC=CC=C3)=C(C#N)C2=O)C=C(Br)C=C1
• Molecular Weight: 367.20
• References & Citations: [1]Cheney IW, et al. Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1679-83.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported