Gü2602

• Description:

  Gü2602 is a potent, reversible cathepsin K (CatK) inhibitor with a Ki of 0.013 nM for mature CatK (mCatK) . Gü2602 suppresses the autocatalytic activation of the cathepsin K zymogen[1].

• UNSPSC:

  12352005

• Target:

  Cathepsin

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/g-2602.html

• Purity:

  98.13

• Solubility:

  DMSO : 66.67 mg/mL (ultrasonic)

• Smiles:

  CN (C (CN (NC (OC (C) (C) C) =O) C#N) =O) CC1=CC=CC=C1

• Molecular Formula:

  C16H22N4O3

• Molecular Weight:

  318.37

• References & Citations:

  [1]Benýšek J, et al. Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes. J Enzyme Inhib Med Chem. 2022 Dec;37 (1) :515-526.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Cathepsin K

• CAS Number:

  1627094-88-5