Gü2602

• Description :

  Gü2602 is a potent, reversible cathepsin K (CatK) inhibitor with a Ki of 0.013 nM for mature CatK (mCatK) . Gü2602 suppresses the autocatalytic activation of the cathepsin K zymogen[1].

• CAS Number :

  [1627094-88-5]

• UNSPSC :

  12352005

• Target :

  Cathepsin

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/g-2602.html

• Purity :

  98.13

• Solubility :

  DMSO : 66.67 mg/mL (ultrasonic)

• Smiles :

  CN(C(CN(NC(OC(C)(C)C)=O)C#N)=O)CC1=CC=CC=C1

• Molecular Formula :

  C16H22N4O3

• Molecular Weight :

  318.37

• References & Citations :

  [1]Benýšek J, et al. Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes. J Enzyme Inhib Med Chem. 2022 Dec;37 (1) :515-526.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Cathepsin K