Products for Research Use Only
RegisterLogin

ZM241385

CAT: 0804-HY-19532-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-19532-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ZM241385 is a potent, high affinity and selective adenosine A2a receptor (A2AR) antagonist with a Ki value of 1.4 nM[1][2][3].
CAS Number
139180-30-6
UNSPSC
12352005
Hazard Statement
H301
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/ZM241385.html
Purity
99.45
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC=C(CCNC2=NC3=NC(C4=CC=CO4)=NN3C(N)=N2)C=C1
Molecular Formula
C16H15N7O2
Molecular Weight
337.34
Precautions
H301
References & Citations
[1]Wang Z, et al. Static magnetic field exposure reproduces cellular effects of the Parkinson's disease drugcandidate ZM241385. PLoS One. 2010 Nov 8;5 (11) :e13883. doi: 10.1371/journal.pone.0013883.|[2]Linden J, et al. Characterization of human A (2B) adenosine receptors: radioligandbinding, western blotting, and coupling to G (q) in human embryonickidney 293 cells and HMC-1 mast cells. Mol Pharmacol. 1999 Oct;56 (4) :705-13.|[3]Poucher SM, et al. The in vitro pharmacology of ZM 241385, a potent, non-xanthine A2a selective adenosinereceptor antagonist. Br J Pharmacol. 1995 Jul;115 (6) :1096-102.|[4]Ludwig S, et al. Impact of combination immunochemotherapies on progression of 4NQO-induced murine oral squamous cell carcinoma. Cancer Immunol Immunother. 2019 Jul;68 (7) :1133-1141.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Adenosine A2A receptor (A2AR)

Alternative Products

CatalogName
C13188-10mgZM241385
SD2407-5mgZM241385 (Adenosine Receptor inhibitor)

Popular Products