Quinine (hydrochloride dihydrate) (Standard)
CAT:
804-HY-B0433AR-01
Size:
25 mg
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Quinine (hydrochloride dihydrate) (Standard)
- CAS Number: 6119-47-7
- UNSPSC Description: Quinine (hydrochloride dihydrate) (Standard) is the analytical standard of Quinine (hydrochloride dihydrate). This product is intended for research and analytical applications. Quinine hydrochloride dihydrate (Qualaquin) is an orally active and can be used in anti-malarial studies. Quinine hydrochloride dihydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM[1][2].
- Target Antigen: Dengue virus; Flavivirus; Parasite; Potassium Channel
- Type: Reference Standards
- Related Pathways: Anti-infection;Membrane Transporter/Ion Channel
- Field of Research: Infection
- Assay Protocol: https://www.medchemexpress.com/quinine-hydrochloride-dihydrate-standard.html
- Smiles: COC1=CC2=C(N=CC=C2[C@H]([C@@]3([H])[N@](C[C@@H]4C=C)CC[C@@]4([H])C3)O)C=C1.Cl.O.O
- Molecular Weight: 396.91
- References & Citations: [1]White, N.J., et al., Quinine pharmacokinetics and toxicity in cerebral and uncomplicated Falciparum malaria. Am J Med, 1982. 73(4): p. 564-72.|[2]Shilu Malakar，et al. Drug repurposing of quinine as antiviral against dengue virus infection. Virus Res. 2018 Aug 15;255:171-178. doi: 10.1016/j.virusres.2018.07.018. Epub 2018 Jul 25.|[3]Jhanwar, Deepika，et al. Chemoprevention of DMBA induced skin carcinogenesis in swiss albino mice by quinine sulfate.(2016): 2636-2640.|[4] Ebenezer O Farombi, et al. Quercetin protects against testicular toxicity induced by chronic administration of therapeutic dose of quinine sulfate in rats. J Basic Clin Physiol Pharmacol. 2012 Feb 27;23(1):39-
- Shipping Conditions: Room temperature