Ondansetron (hydrochloride dihydrate)

• UNSPSC Description:

  Ondansetron (GR 38032) hydrochloride dehydrate is an orally active, highly selective and competitive 5-HT3 receptor antagonist (crosses the blood-brain barrier). Ondansetron hydrochloride dehydrate can be used in studies of preventing nausea and vomiting associated with cancer chemotherapy, radiation therapy and surgery[1][2].

• Target Antigen:

  5-HT Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Ondansetron-hydrochloride-dihydrate.html

• Purity:

  99.94

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)|H2O : 16.67 mg/mL (ultrasonic)

• Smiles:

  O=C1C(CN2C=CN=C2C)CCC(N3C)=C1C4=C3C=CC=C4.[H]Cl.O.O

• Molecular Weight:

  365.85

• References & Citations:

  [1]Yamamoto K, et al. Ondansetron, dexamethasone and an NK1 antagonist block radiation sickness in mice. Pharmacol Biochem Behav. 2005 Sep;82(1):24-9. |[2]Wilde MI, et al. Ondansetron. A review of its pharmacology and preliminary clinical findings in novel applications. Drugs. 1996 Nov;52(5):773-94. Eur J Pharm Sci. 2023 May 22;106475.|Int J Pharm. 2015 Dec 30;496(1):33-41.|Patent. US20170319486A1.|Front Pharmacol. 2024 Aug 21:15:1443169.|J Ethnopharmacol. 2024 Jan 5:117703.|Journal of Radiation Research and Applied Sciences. 2023 Dec, 16(4), 100682.|Prog Neuropsychopharmacol Biol Psychiatry. 2022 Nov 30;110689.|SSRN. 2023 Srep 5.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Clinical Information:

  Launched

• CAS Number:

  103639-04-9