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Aurora A Rabbit pAb

CAT: 0855-ES20863-01Size: 50 µLDry Ice: NoHazardous: No
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Background
Aurora A (AURKA) Homo sapiens The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene.
Description
Aurora A (AURKA) Homo sapiens The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene.
Product Name Alternative
Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (hARK1) (Breast tumor-amplified kinase) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase aurora-A)
UniProt
O14965
Swiss Prot
O14965
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human Aurora A AA range: 65-115
Target
Aurora A
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; WB
Concentration
1 mg/ml
Dilution
IHC-p1:50-200 , WB 1:1000-2000
Buffer
-20°C/1 year
Molecular Weight
46kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
46kD
Fragment
IgG
Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cell projection, neuron projection . Detected at the neurite hillock in developing neurons (By similarity) . Localizes at the centrosome in mitotic cells from early prophase until telophase, but also localizes to the spindle pole MTs from prophase to anaphase (PubMed:9606188, PubMed:17229885, PubMed:21225229) . Colocalized with SIRT2 at centrosome (PubMed:22014574) . Moves to the midbody during both telophase and cytokinesis (PubMed:17726514) . Associates with both the pericentriolar material (PCM) and centrioles (PubMed:22014574) . The localization to the spindle
Other Product Names
Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (hARK1) (Breast tumor-amplified kinase) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase aurora-A)
Gene ID (Human)
6790

UniProtKB · O14965

Aurora kinase A

AURKA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O14965
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
AURKA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.1
Processing
—
Secondary accessions
E1P5F9, O60445, O75873, Q9BQD6, Q9UPG5
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Ligand

ATP-bindingNucleotide-binding

Biological process

Cell cycleCell divisionCilium biogenesis/degradationMitosis

Cellular component

Cell membraneCell projectionCiliumCytoplasmCytoskeletonMembraneMicrotubule

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

Disease

Proto-oncogene

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