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MARCH8 Antibody

CAT: 0247-OAPB00784-100UGSize: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0247-OAPB00784-100UGSize:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
Membrane associated ring-CH-type finger 8
Gene Aliases
Cellular modulator of immune recognition; cellular modulator of immune recognition (c-MIR) ; c-MIR; CMIR; c-mir, cellular modulator of immune recognition; E3 ubiquitin-protein ligase MARCH8; E3 ubiquitin-protein ligase MARCHF8; MARCH8; MARCH-VIII; membrane associated ring finger 8; membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase; membrane-associated RING finger protein 8; membrane-associated RING-CH protein VIII; MIR; RING finger protein 178; RING-type E3 ubiquitin transferase MARCH8; RING-type E3 ubiquitin transferase MARCHF8; RNF178.
Gene ID
220972
Accession Number
https://www.ncbi.nlm.nih.gov/protein/NP_659458
Reactivity
Bovine|Human|Mouse|Rat
Immunogen
MARCH8 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human MARCH8. The immunogen is located within the last 50 amino acids of MARCH8.
Target
E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunocytochemistry|Western blot
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Homology
Human; Mouse; Rat
Format
Liquid. MARCH8 Antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution
MARCH8 antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
NCBI Gene Symbol
MARCHF8
Host or Source
Rabbit
Protein Name
E3 ubiquitin-protein ligase MARCH8|E3 ubiquitin-protein ligase MARCH8 isoform a [Homo sapiens]
Gene Name URL
MARCHF8