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CXCR4 Antibody

CAT: 0247-OAPB00002-100UGSize: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0247-OAPB00002-100UGSize:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
C-X-C motif chemokine receptor 4
Gene Aliases
CD184; CD184 antigen; chemokine (C-X-C motif) receptor 4; C-X-C chemokine receptor type 4; D2S201E; FB22; fusin; HM89; HSY3RR; LAP3; LAP-3; LCR1; LESTR; leukocyte-derived seven transmembrane domain receptor; lipopolysaccharide-associated protein 3; LPS-associated protein 3; neuropeptide Y receptor Y3; neuropeptide Y3 receptor; NPY3R; NPYR; NPYRL; NPYY3R; SDF-1 receptor; seven transmembrane helix receptor; seven-transmembrane-segment receptor, spleen; stromal cell-derived factor 1 receptor; WHIM; WHIMS; WHIMS1.
Gene ID
7852
Accession Number
https://www.ncbi.nlm.nih.gov/protein/NP_003458
Reactivity
Bovine|Human|Mouse|Porcine|Rat
Immunogen
Anti-CXCR4 antibody (1009) was raised against a peptide corresponding to 14 amino acids near the amino terminus of human CXCR4 isoform b. The immunogen is located within the first 50 amino acids of CXCR4.
Target
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Flow cytometry|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Paraffin|Immunoprecipitation|Western blot
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Homology
Bovine (86%), Pig (71%), Rat (71%)
Format
Liquid. CXCR4 Antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution
CXCR4 antibody can be stored at 4C for three months and -20C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight
Predicted: 40 kDa Observed: 44 kDa (Post-modification: 2 N-linked glycosylation)
Fragment
IgG
Specificity
CXCR4 Antibody is predicted to not cross-react with other CXCR familiy members.
NCBI Gene Symbol
CXCR4
Host or Source
Rabbit
Protein Name
C-X-C chemokine receptor type 4|C-X-C chemokine receptor type 4 isoform b [Homo sapiens]
Gene Name URL
CXCR4

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