PTPRC Antibody

• Gene Name:

  Receptor-type tyrosine-protein phosphatase C

• Gene Aliases:

  LCA, LY5, B220, CD45, L-CA, T200, CD45R, GP180

• Gene ID:

  5788

• Accession Number:

  NP_002829.3NP_563578.2

• Reactivity:

  Cat|Human|Mouse

• Immunogen:

  Abelson murine leukemia virus-induced pre-B tumor cells

• Target:

  CD45R, also known as B220, is a receptor-type protein tyrosine phosphatase glycoprotein. It is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45R expression also identifies a subset of murine bone marrow cells able to form osteoclast-like cells.

• Clonality:

  Monoclonal

• Clone:

  RA3-6B2

• Type:

  Monoclonal Antibody

• Applications:

  Flow cytometry|Immunocytochemistry|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Immunoprecipitation

• Purification:

  Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  1 mg/ml

• Format:

  Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

• Reconstitution:

  2°C to 8°C

• Fragment:

  IgG2a

• Specificity:

  The rat monoclonal antibody RA3-6B2 recognizes an epitope on CD45R, which is expressed at all developmental stages of B cells, including activated B cells, but also on subsets of NK and T cells. T cells detected by this antibody are supposed to be in activated state.

• NCBI Gene Symbol:

  PTPRC

• Host or Source:

  Rat

• Protein Name:

  Receptor-type tyrosine-protein phosphatase C

• Gene Name URL:

  PTPRC

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_002838.4NM_080921.3