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PTPRC Antibody

CAT: 0223-56-003Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-56-003Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq].
NCBI Gene ID
5788
Swiss Prot
P08575
Accession Number
P08575
Host
Rabbit
Reactivity
Human
Immunogen
This PTPRC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-364 amino acids from the N-terminal region of human PTPRC.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Immunology, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
147 kDa
Fragment
Rabbit Ig
Symbol
PTPRC
NCBI Official Name
Receptor-type tyrosine-protein phosphatase C
NCBI Organism
Homo sapiens
Background Reference 01
Heyd, F., et al. Mol. Cell 40 (1) :126-137 (2010)
Background Reference 02
Wu, Z., et al. J. Immunol. 185 (1) :231-238 (2010)
Background Reference 03
Cui, J., et al. Arthritis Rheum. 62 (7) :1849-1861 (2010)
Background Reference 04
Booth, N.J., et al. J. Immunol. 184 (8) :4317-4326 (2010)
Other Product Names
Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, L-CA, T200, CD45, PTPRC, CD45
Tested Applications
WB, Flow
Protein ID
33112650
Physical Properties
Liquid

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