PTPRC Antibody

CAT: 0223-18-513Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-18-513Size:100 µL
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Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
NCBI Gene ID
5788
Swiss Prot
P08575
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 890-990 of human PTPRC (NP_002829.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cell Cycle, Immunology, Neuroscience, Signal Transduction, Stem Cell
Purification
Affinity purification
Positive Control
Mouse thymus
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 185kDa
Fragment
IgG
Symbol
PTPRC
NCBI Official Name
Protein tyrosine phosphatase, receptor type, C
NCBI Organism
Homo sapiens
Other Product Names
Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, L-CA, T200, CD45, PTPRC, CD45
Tested Applications
WB, IHC, IF
Physical Properties
Liquid

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