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PTPRC Antibody

CAT: 0247-OAEE00256-100UGSize: 0.1 mg (C100)Dry Ice: NoHazardous: No
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CAT#:0247-OAEE00256-100UGSize:0.1 mg (C100)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
Receptor-type tyrosine-protein phosphatase C
Gene Aliases
LCA, LY5, B220, CD45, L-CA, T200, CD45R, GP180
Gene ID
5788
Accession Number
NP_002829.3NP_563578.2
Reactivity
Human|Non-human Primate
Immunogen
Human thymocytes and T lymphocytes.
Target
CD45RB is an of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RB is expressed e.g. in microglia and inflammatory cells.
Clonality
Monoclonal
Clone
MEM-55
Type
Monoclonal Antibody
Applications
Flow cytometry|Immunohistochemistry-Paraffin|Immunoprecipitation|Western blot
Purification
Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Reconstitution
2°C to 8°C
Fragment
IgG1
Specificity
HLDA III; WS Code NL 358 HLDA IV; WS Code NL 2 HLDA V; WS Code T T-151 HLDA V; WS Code T T-CD45.08 //
NCBI Gene Symbol
PTPRC
Host or Source
Mouse
Protein Name
Receptor-type tyrosine-protein phosphatase C
Gene Name URL
PTPRC
Nucleotide Accession Number
NM_002838.4NM_080921.3

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