PTPRC Antibody

• Gene Name:

  Receptor-type tyrosine-protein phosphatase C

• Gene Aliases:

  LCA, LY5, B220, CD45, L-CA, T200, CD45R, GP180

• Gene ID:

  5788

• Accession Number:

  NP_002829.3NP_563578.2

• Reactivity:

  Human|Non-human Primate

• Immunogen:

  Human thymocytes and T lymphocytes.

• Target:

  CD45RB is an of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RB is expressed e.g. in microglia and inflammatory cells.

• Clonality:

  Monoclonal

• Clone:

  MEM-55

• Type:

  Monoclonal Antibody

• Applications:

  Flow cytometry|Immunohistochemistry-Paraffin|Immunoprecipitation|Western blot

• Purification:

  Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  1 mg/ml

• Format:

  Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

• Reconstitution:

  2°C to 8°C

• Fragment:

  IgG1

• Specificity:

  HLDA III; WS Code NL 358 HLDA IV; WS Code NL 2 HLDA V; WS Code T T-151 HLDA V; WS Code T T-CD45.08 //

• NCBI Gene Symbol:

  PTPRC

• Host or Source:

  Mouse

• Protein Name:

  Receptor-type tyrosine-protein phosphatase C

• Gene Name URL:

  PTPRC

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_002838.4NM_080921.3