RUNX1T1 Antibody

• Gene Name:

  RUNX1 translocation partner 1

• Gene Aliases:

  CDR, ETO, MTG8, AML1T1, ZMYND2, CBFA2T1, AML1-MTG8

• Gene ID:

  862

• Accession Number:

  NP_001185554.1

• Reactivity:

  Human

• Target:

  This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t (8;21) (q22; q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  CHIP

• Purification:

  Whole antiserum

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  Undetermined, ascites

• Format:

  Liquid. Whole antiserum from rabbit containing 0.05% azide.

• Reconstitution:

  Store at -20C. Avoid repeated freeze/thaw cycles.

• Specificity:

  Polyclonal antibody raised in rabbit against human ETO (runt-related transcription factor 1; translocated to, 1 (cyclin D-related) ) using two KLH-conjugated synthetic peptides containing sequences from the N-terminal and the central region of the protein, respectively.

• NCBI Gene Symbol:

  RUNX1T1

• Host or Source:

  Rabbit

• Protein Name:

  Protein CBFA2T1

• Gene Name URL:

  RUNX1T1

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_001198625.1