Arecoline (hydrochloride)

Arecoline (hydrochloride)

• CAS Number: 61-94-9
• UNSPSC Description: Arecoline hydrochloride, a naturally occurring psychoactive alkaloid, is a partial agonist of nicotinic and muscarinic acetylcholine receptor. Arecoline hydrochloride exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline hydrochloride also can induce oxidative stress[1][2][3][4].
• Target Antigen: mAChR; nAChR
• Type: Natural Products
• Related Pathways: GPCR/G Protein;Membrane Transporter/Ion Channel;Neuronal Signaling
• Field of Research: Cancer; Infection; Metabolic Disease; Inflammation/Immunology; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/arecoline-hydrochloride.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(OC)C1=CCCN(C1)C.[H]Cl
• Molecular Weight: 191.66
• References & Citations: [1]Thangjam GS, et, al. Regulation of oxidative-stress responsive genes by arecoline in human keratinocytes. J Periodontal Res. 2009 Oct;44(5):673-82.|[2]Liu YJ, et, al. The pharmacology, toxicology and potential applications of arecoline: a review. Pharm Biol. 2016 Nov;54(11):2753-2760.|[3]Volgin AD, et, al. DARK Classics in Chemical Neuroscience: Arecoline. ACS Chem Neurosci. 2019 May 15;10(5):2176-2185. |[4]Kuo TM, et, al. Arecoline induces TNF-alpha production and Zonula Occludens-1 redistribution in mouse Sertoli TM4 cells. J Biomed Sci. 2014 Sep 9;21(1):93.Int J Mol Sci. 2023 Mar 28.|J Oral Pathol Med. 2022 Sep 2.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported