Arecoline

• Description:

  Arecoline, a naturally occurring psychoactive alkaloid, is a partial agonist of nicotinic and muscarinic acetylcholine receptor. Arecoline exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline also can induce oxidative stress[1][2][3][4].

• UNSPSC:

  12352005

• Target:

  MAChR; nAChR

• Type:

  Natural Products

• Related Pathways:

  GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Cancer; Infection; Metabolic Disease; Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/arecoline.html

• Purity:

  99.84

• Solubility:

  DMSO : 100 mg/mL (ultrasonic) |H2O : 250 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=CCCN(C)C1)OC

• Molecular Formula:

  C8H13NO2

• Molecular Weight:

  155.19

• References & Citations:

  [1]G S Thangjam, et al. Regulation of oxidative-stress responsive genes by arecoline in human keratinocytes. J Periodontal Res. 2009 Oct;44 (5) :673-82.|[2]Liu YJ, et, al. The pharmacology, toxicology and potential applications of arecoline: a review. Pharm Biol. 2016 Nov;54 (11) :2753-2760.|[3]Volgin AD, et, al. DARK Classics in Chemical Neuroscience: Arecoline. ACS Chem Neurosci. 2019 May 15;10 (5) :2176-2185. |[4]Kuo TM, et, al. Arecoline induces TNF-alpha production and Zonula Occludens-1 redistribution in mouse Sertoli TM4 cells. J Biomed Sci. 2014 Sep 9;21 (1) :93.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  Phase 1

• Citation 01:

  Ecotoxicol Environ Saf. 2025 Mar 26:294:118108.|Int J Mol Sci. 2023 Mar 28;24 (7) :6327.|J Oral Pathol Med. 2022 Oct;51 (9) :780-790.

• CAS Number:

  [63-75-2]