Arecoline

CAT: 0804-HY-N2364-01Size: 50 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N2364-01Size:50 mg
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Description
Arecoline, a naturally occurring psychoactive alkaloid, is a partial agonist of nicotinic and muscarinic acetylcholine receptor. Arecoline exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline also can induce oxidative stress[1][2][3][4].
CAS Number
[63-75-2]
UNSPSC
12352005
Target
MAChR; nAChR
Type
Natural Products
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Infection; Metabolic Disease; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/arecoline.html
Purity
99.84
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 250 mg/mL (ultrasonic)
Smiles
O=C(C1=CCCN(C)C1)OC
Molecular Formula
C8H13NO2
Molecular Weight
155.19
References & Citations
[1]G S Thangjam, et al. Regulation of oxidative-stress responsive genes by arecoline in human keratinocytes. J Periodontal Res. 2009 Oct;44 (5) :673-82.|[2]Liu YJ, et, al. The pharmacology, toxicology and potential applications of arecoline: a review. Pharm Biol. 2016 Nov;54 (11) :2753-2760.|[3]Volgin AD, et, al. DARK Classics in Chemical Neuroscience: Arecoline. ACS Chem Neurosci. 2019 May 15;10 (5) :2176-2185. |[4]Kuo TM, et, al. Arecoline induces TNF-alpha production and Zonula Occludens-1 redistribution in mouse Sertoli TM4 cells. J Biomed Sci. 2014 Sep 9;21 (1) :93.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
Phase 1
Citation 01
Ecotoxicol Environ Saf. 2025 Mar 26:294:118108.|Int J Mol Sci. 2023 Mar 28;24 (7) :6327.|J Oral Pathol Med. 2022 Oct;51 (9) :780-790.

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