SET2

CAT: 0804-HY-132222-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-132222-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SET2 is a selective TRPV2 antagonist (IC50=0.46 μM) . SET2 blocks the TRP channel and suppresses prostate cancer cells migration. SET2 reduces the lysophosphatidic acid (LPA, a TRPV2 activator) -induced cytoplasmic calcium increases[1].
CAS Number
[2313525-20-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/set2.html
Purity
99.78
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(CCSC1=NC(C(F)(F)F)=CC(N(CCC)C)=N1)NCC2=CC=CO2
Molecular Formula
C17H21F3N4O2S
Molecular Weight
402.43
Precautions
H302, H315, H319
References & Citations
[1]Chai H, et al. Structure-Based Discovery of a Subtype-Selective Inhibitor Targeting a Transient Receptor Potential Vanilloid Channel. J Med Chem. 2019 Feb 14;62 (3) :1373-1384.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPV2

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