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BCAR3 Antibody

CAT: 0247-OAAJ02077-100ULSize: 100 µLDry Ice: NoHazardous: No
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CAT#:0247-OAAJ02077-100ULSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
Breast cancer anti-estrogen resistance 3
Gene Aliases
MIG7, NSP2, AND-34, SH2D3B
Gene ID
8412
Swiss Prot
O75815
Reactivity
Human
Immunogen
A synthesized peptide derived from human BCAR3
Target
A ubiquitously expressed regulator of R-Ras activity that has been implicated in breast cancer. A GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1. Can accelerate the degradation of IRS-1, thus regulating signaling through the insulin receptor. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins. Up-regulated by interleukin-1-alpha and TNF-beta in thymus cortical reticular cell lines (mouse) .Two alternatively spliced human isoforms have been described.
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
WB, IHC
Purification
Immunogen affinity purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Liquid. Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Reconstitution
Store at -20C. Stable for 12 months from date of receipt.
Molecular Weight
92 kDa
Specificity
BCAR3 antibody detects endogenous levels of BCAR3
NCBI Gene Symbol
BCAR3
Host or Source
Rabbit
Gene Name URL
BCAR3

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