TFRC Antibody (Phospho-Ser24)

• Description:

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• Gene Name:

  Myelin basic protein|transferrin receptor

• Gene Aliases:

  CD71; Golli-MBP; IMD46; myelin A1 protein; myelin basic protein; myelin membrane encephalitogenic protein; p90; proline-rich proteoglycan 2; T9; TFR; TFR1; TR; transferrin receptor protein 1; TRFR.

• Gene ID:

  4155|7037

• Swiss Prot:

  P02786

• Accession Number:

  NP_001121620.1

• Reactivity:

  Human|Mouse

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human CD71/TfR around the phosphorylation site of Ser24.

• Target:

  Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity) . A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240) .

• Clonality:

  Polyclonal

• Type:

  Polyclonal Antibody

• Applications:

  Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Dilution:

  The optimal working dilution should be determined by the end user.

• Format:

  Liquid

• Reconstitution:

  -20°C

• Molecular Weight:

  84 kDa

• Notes:

  Formerly GWB-ASB380

• Specificity:

  CD71/TfR (Phospho-Ser24) antibody detects endogenous levels of CD71/TfR only when phosphorylated at serine 24.

• NCBI Gene Symbol:

  MBP|TFRC

• Host or Source:

  Rabbit

• Protein Name:

  Transferrin receptor protein 1

• Gene Name URL:

  MBP|TFRC

• CAS Number:

  9007-83-4