TFRC Antibody

• Gene Name :

  Transferrin receptor

• Gene Aliases :

  CD71; IMD46; p90; T9; TFR; TFR1; TR; transferrin receptor protein 1; TRFR.

• Gene ID :

  7037

• Accession Number :

  NP_001121620.1NP_003225.2

• Reactivity :

  Human

• Immunogen :

  NALM-6 human pre-B cell line

• Target :

  Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity) . A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240) .

• Clonality :

  Monoclonal

• Clone :

  MEM-75

• Conjugation :

  APC

• Type :

  Monoclonal Antibody

• Applications :

  Flow cytometry

• Purification :

  Purified by size-exclusion chromatography

• Assay Protocol :

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration :

  10 ul / test

• Format :

  Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

• Buffer :

  The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.

• Reconstitution :

  2°C to 8°C

• Fragment :

  IgG1

• Specificity :

  HLDA IV; WS Code A 45 HLDA V; WS Code T T-165//

• NCBI Gene Symbol :

  TFRC

• Host or Source :

  Mouse

• Protein Name :

  Transferrin receptor protein 1

• Gene Name URL :

  TFRC

• CAS Number :

  9007-83-4

• Nucleotide Accession Number :

  NM_001128148.1NM_003234.2