TFRC Antibody

CAT: 0247-OASG01348-100ULSize: 100 µLDry Ice: NoHazardous: No
CAT#:0247-OASG01348-100ULSize:100 µL
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CAS Number
9007-83-4
Gene Name
Transferrin receptor
Gene Aliases
T9, TR, TFR, p90, CD71, TFR1, TRFR, IMD46
Gene ID
7037
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived between 10-90 aa from human CD71 around the non-phosphorylation site of S24.
Target
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system . A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake . (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus.
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
WB, IHC
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Liquid.// PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Reconstitution
Store at -20° C. Avoid repeat freeze-thaw cycles.
Molecular Weight
89 kDa
Fragment
IgG
Specificity
CD71 Polyclonal Antibody detects endogenous levels of CD71 protein.
NCBI Gene Symbol
TFRC
Host or Source
Rabbit
Gene Name URL
TFRC

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