CCNH Antibody - C-terminal region

• Gene Name:

  Cyclin H

• Gene Aliases:

  CAK, p34, p37, CycH

• Gene ID:

  902

• Swiss Prot:

  P51946

• Accession Number:

  NP_001230

• Reactivity:

  Human, Mouse, Rat, Guinea Pig, Horse, Rabbit

• Immunogen:

  The immunogen is a synthetic peptide directed towards the C terminal region of human CCNH

• Target:

  Cyclin H regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive carboxyl-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. It is involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

• Partner Proteins:

  SFN; GOLGA2; SSX2IP; CCDC170; CCDC33; DUSP12; SSSCA1; NDC80; CALCOCO2; PPFIA1; PSMA1; KLC3; RPA3; RPA2; RPA1; NEDD4; CDK7; CDK8; CDK2; CCNC; MNAT1; MBP; CTD; CDK20; CTBP2; CSNK2B; TRIM8; GANAB; RARB; POLR2A; GTF2H4; ERCC2; tat; POLR2B; CDK9; BRCA1; GTF2H1

• Clonality:

  Polyclonal

• Type:

  Polyclonal Antibody

• Sequence:

  KQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL

• Applications:

  IHC, WB

• Purification:

  Protein A purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  1.0 mg/ml

• Homology:

  Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 83%; Rabbit: 83%; Rat: 83%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Reconstitution:

  For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

• Molecular Weight:

  38 kDa

• Protein Length:

  323

• NCBI Gene Symbol:

  CCNH

• Host or Source:

  Rabbit

• Protein Name:

  Cyclin-H

• Gene Name URL:

  CCNH

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_001239