CCNH Antibody - C-terminal region: Biotin (AVARP03026_T100-Biotin)

• Gene Name:

  Cyclin H

• Gene Aliases:

  CAK, p34, p37, CycH

• Gene ID:

  902

• Swiss Prot:

  P51946

• Accession Number:

  NP_001230

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Guinea Pig, Horse, Rabbit

• Immunogen:

  The immunogen is a synthetic peptide directed towards the C terminal region of human CCNH

• Target:

  Cyclin H regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive carboxyl-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. It is involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

• Partner Proteins:

  SFN; GOLGA2; SSX2IP; CCDC170; CCDC33; DUSP12; SSSCA1; NDC80; CALCOCO2; PPFIA1; PSMA1; KLC3; RPA3; RPA2; RPA1; NEDD4; CDK7; CDK8; CDK2; CCNC; MNAT1; MBP; CTD; CDK20; CTBP2; CSNK2B; TRIM8; GANAB; RARB; POLR2A; GTF2H4; ERCC2; tat; POLR2B; CDK9; BRCA1; GTF2H1

• Clonality:

  Polyclonal

• Conjugation:

  Biotin

• Type:

  Polyclonal Antibody

• Applications:

  IHC, WB

• Sample Type:

  CCNH is supported by BioGPS gene expression data to be expressed in Jurkat

• Concentration:

  0.5 mg/mL

• Homology:

  Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 83%; Rabbit: 83%; Rat: 83%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  38kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  323

• NCBI Gene Symbol:

  CCNH

• Protein Name:

  Cyclin-H

• Nucleotide Accession Number:

  NM_001239