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Sulfanilamide-d4

CAT: 0804-HY-B0242S1-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0242S1-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sulfanilamide-d4 is the deuterium labeled Sulfanilamide. Sulfanilamide is a competitive inhibitor for bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.
CAS Number
77435-46-2
Product Name Alternative
Sulphanilamide-d4
UNSPSC
12352005
Target
Antibiotic; Bacterial
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection
Field of Research
Infection
Purity
99.99
Solubility
10 mM in DMSO|DMSO : 100mg/mL (ultrasonic) |H2O : 10mg/mL (ultrasonic)
Smiles
NS(=O)(C1=C([2H])C([2H])=C(C([2H])=C1[2H])N)=O
Molecular Formula
C6H4D4N2O2S
Molecular Weight
176.23
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]McCullough, J.L. and T.H. Maren, Inhibition of dihydropteroate synthetase from Escherichia coli by sulfones and sulfonamides. Antimicrob Agents Chemother, 1973. 3 (6) : p. 665-9.|[3]Meneau, I., et al., Pneumocystis jiroveci dihydropteroate synthase polymorphisms confer resistance to sulfadoxine and sulfanilamide in Saccharomyces cerevisiae. Antimicrob Agents Chemother, 2004. 48 (7) : p. 2610-6.|[4]Hughes, W.T. and J. Killmar, Monodrug efficacies of sulfonamides in prophylaxis for Pneumocystis carinii pneumonia. Antimicrob Agents Chemother, 1996. 40 (4) : p. 962-5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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