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DL-Mevalonolactone (Standard)

CAT: 0804-HY-107855R-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107855R-01Size:10 mg
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Description
DL-Mevalonolactone (Standard) is the analytical standard of DL-Mevalonolactone. This product is intended for research and analytical applications. DL-Mevalonolactone ((±) -Mevalonolactone; Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone is orally active against HMGCR mutation and statin caused myopathy[3]. DL-Mevalonolactone induces inflammation and oxidative stress response with decreased mitochondrial membrane potential (MMP) and induces mitochondrial swelling[2][4].
CAS Number
674-26-0
Product Name Alternative
(±) -Mevalonolactone (Standard) ; Mevalolactone (Standard)
UNSPSC
12352100
Target
Endogenous Metabolite; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Metabolic Disease; Inflammation/Immunology
Smiles
O=C1CC(C)(O)CCO1
Molecular Formula
C6H10O3
Molecular Weight
130.14
References & Citations
[1]Domingos SR, et al. On the structural intricacies of a metabolic precursor: Direct spectroscopic detection of water-induced conformational reshaping of mevalonolactone. J Chem Phys. 2017 Sep 28;147 (12) :124310.|[2]Cecatto C, et al. Mevalonolactone disrupts mitochondrial functions and induces permeability transition pore opening in rat brain mitochondria: Implications for the pathogenesis of mevalonic aciduria. Neurochem Int. 2017 Sep;108:133-145.|[3]Yogev Y, et al., Limb girdle muscular disease caused by HMGCR mutation and statin myopathy treatable with mevalonolactone. Proc Natl Acad Sci U S A. 2023 Feb 14;120 (7) :e2217831120.|[4]Gratton R, et al., Prolonged treatment with mevalonolactone induces oxidative stress response with reactive oxygen species production, mitochondrial depolarization and inflammation in human glioblastoma U-87 MG cells. Neurochem Int. 2018 Nov;120:233-237.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Clinical Information
No Development Reported

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