Falnidamol

• Target:

  EGFR

• Related Pathways:

  Tyrosine Kinase/Adaptors|||JAK/STAT signaling|||Angiogenesis

• Purity:

  0.9882

• Bioactivity:

  Falnidamol (BIBX 1382) is an orally active, selective EGFR tyrosine kinase inhibitor with an IC50 of 3 nM. It displays >1000-fold lower potency against ErbB2 (IC50=3.4 ?M) and other related tyrosine kinases (IC50>10 ?M) . Falnidamol is a pyrimido-pyrimidine compound and exhibits anti-cancer activity.

• Smiles:

  CN1CCC(CC1)Nc1ncc2ncnc(Nc3ccc(F)c(Cl)c3)c2n1

• Molecular Formula:

  C18H19ClFN7

• Molecular Weight:

  387.84

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  196612-93-8