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Ko 143

CAT: 0931-TQ0186-07Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-TQ0186-07Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
461054-93-3
Target
BCRP, ABC Transporter
Related Pathways
Membrane transporter/Ion channel
Purity
0.9989
Bioactivity
Ko 143 is a selective inhibitor of ATP-binding cassette sub-family G member 2 (ABCG2; BCRP) .
Smiles
COc1ccc2c3C[C@@H]4N([C@@H](CC(C)C)c3[nH]c2c1)C(=O)[C@H](CCC(=O)OC(C)(C)C)NC4=O
Molecular Formula
C26H35N3O5
Molecular Weight
469.57
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Ko 143

LSM-6260 is a tert-butyl ester and a member of beta-carbolines.

CAS Number461054-93-3
PubChem CID10322450
IUPAC Nametert-butyl 3-[(2S,5S,8S)-14-methoxy-2-(2-methylpropyl)-4,7-dioxo-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraen-5-yl]propanoate
Molecular FormulaC26H35N3O5
Molecular Weight469.6
XLogP3.5
Topological Polar Surface Area101
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Heavy Atom Count34
Formal Charge0
Complexity794
SMILES
CC(C)C[C@H]1C2=C(C[C@@H]3N1C(=O)[C@@H](NC3=O)CCC(=O)OC(C)(C)C)C4=C(N2)C=C(C=C4)OC
InChI
InChI=1S/C26H35N3O5/c1-14(2)11-20-23-17(16-8-7-15(33-6)12-19(16)27-23)13-21-24(31)28-18(25(32)29(20)21)9-10-22(30)34-26(3,4)5/h7-8,12,14,18,20-21,27H,9-11,13H2,1-6H3,(H,28,31)/t18-,20-,21-/m0/s1
InChIKey
NXNRAECHCJZNRF-JBACZVJFSA-N
Chemical Structure
2D Structure
2D structure of Ko 143
CAS: 461054-93-3
CID: 10322450
Formula: C26H35N3O5
MW: 469.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight469.6
XLogP33.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Exact Mass469.25767123
Monoisotopic Mass469.25767123
Topological Polar Surface Area101 Ų
Heavy Atom Count34
Formal Charge0
Complexity794
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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