MM 54

• Target :

  Apelin receptor

• Related Pathways :

  GPCR/G Protein

• Bioactivity :

  Potent apelin receptor antagonist (Ki = 82 nM; IC50 = 93 nM) . Antagonizes the inhibitory affect of [Pyr1]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells. Recuces tumor expansion and lengthens survival time in a mouse xenograft model of glioblastoma.

• Smiles :

  O=C1N2[C@@](CCC2)(C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(O)=O)CSSC[C@H](NC([C@H](CC3=CN=CN3)NC([C@@H](NC(=O)[C@H]4NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@]5(N(C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CSSC4)CCC5)[H])CCCCN)=O)=O)C(=O)N[C@H]1CCCNC(=N)N)[H]

• Molecular Formula :

  C70H121N29O15S4

• Molecular Weight :

  1737.15

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1313027-43-8