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MM 07

CAT: 0931-TP2000Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-TP2000Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1876450-21-3
Target
Apelin receptor
Related Pathways
GPCR/G Protein
Bioactivity
Apelin biased agonist; exhibits bias for the G protein pathway. Stimulates endothelial NOS phosphorylation and expression, promotes proliferation, and attenuates apoptosis of human pulmonary arterial endothelial cells in vitro. Shows positive inotropic and vasodilatory effects in vivo and improves cardiac structure and function in a model of pulmonary arterial hypertension.
Smiles
[H][C@@]12CCCN1C(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Molecular Formula
C67H106N22O14S3
Molecular Weight
1539.9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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