HS024

• Target:

  Melanocortin Receptor

• Related Pathways:

  GPCR/G Protein|||Neuroscience

• Purity:

  >99.99%

• Bioactivity:

  HS024 is a highly potent melanocortin MC4 receptor antagonist (Ki values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively) . Increases food intake, and blocks ?-MSH- and MTII-induced hypotension and bradycardia in rats, following central administration in vivo.

• Smiles:

  C(C=1C=2C(NC1)=CC=CC2)[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](CC4=CC5=C(C=C4)C=CC=C5)NC(=O)[C@H](CC6=CN=CN6)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCC)NC(=O)[C@@H](NC(C)=O)CSSC[C@@H](C(N)=O)NC(=O)CNC3=O

• Molecular Formula:

  C58H79N19O10S2

• Molecular Weight:

  1266.5

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  212370-59-7