HS024

• Target:

  Melanocortin Receptor

• Related Pathways:

  GPCR/G Protein|||Neuroscience

• Purity:

  >99.99%

• Bioactivity:

  HS024 is a highly potent melanocortin MC4 receptor antagonist (Ki values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively) . Increases food intake, and blocks ?-MSH- and MTII-induced hypotension and bradycardia in rats, following central administration in vivo.

• Smiles:

  C (C=1C=2C (NC1) =CC=CC2) [C@@H]3NC (=O) [C@H] (CCCNC (=N) N) NC (=O) [C@@H] (CC4=CC5=C (C=C4) C=CC=C5) NC (=O) [C@H] (CC6=CN=CN6) NC (=O) [C@H] (CCCNC (=N) N) NC (=O) [C@H] (CCCC) NC (=O) [C@@H] (NC (C) =O) CSSC[C@@H] (C (N) =O) NC (=O) CNC3=O

• Molecular Formula:

  C58H79N19O10S2

• Molecular Weight:

  1266.5

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  212370-59-7