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2'-O-Methyl-5-iodouridine

CAT: 0931-TNU0630Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0931-TNU0630Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
34218-84-3
Target
Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis
Related Pathways
Apoptosis, Cell Cycle/Checkpoint, DNA Damage/DNA Repair
Purity
0.9989
Bioactivity
2'-O-Methyl-5-iodouridine (5-Iodo-2'-O-methyluridine) is a purine nucleoside analog that targets malignant tumors of the inert lymphatic system and possesses a broad spectrum of antitumor activity. The anticancer mechanism of 2'-O-Methyl-5-iodouridine is dependent on the inhibition of DNA synthesis and induction of apoptosis.
Smiles
O(C)[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)NC(=O)C(I)=C2
Molecular Formula
C10H13IN2O6
Molecular Weight
384.12
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

5-Iodo-2'-O-methyluridine
CAS Number34218-84-3
PubChem CID10317833
IUPAC Name1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-5-iodopyrimidine-2,4-dione
Molecular FormulaC10H13IN2O6
Molecular Weight384.12
XLogP-1.4
Topological Polar Surface Area108
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count19
Formal Charge0
Complexity428
SMILES
CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)I)CO)O
InChI
InChI=1S/C10H13IN2O6/c1-18-7-6(15)5(3-14)19-9(7)13-2-4(11)8(16)12-10(13)17/h2,5-7,9,14-15H,3H2,1H3,(H,12,16,17)/t5-,6-,7-,9-/m1/s1
InChIKey
PLVDDNNLEWFJNQ-JXOAFFINSA-N
Chemical Structure
2D Structure
2D structure of 5-Iodo-2'-O-methyluridine
CAS: 34218-84-3
CID: 10317833
Formula: C10H13IN2O6
MW: 384.12
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight384.12
XLogP3-1.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass383.98183
Monoisotopic Mass383.98183
Topological Polar Surface Area108 Ų
Heavy Atom Count19
Formal Charge0
Complexity428
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
BUP158192'-O-Methyl-5-iodouridine
GTR19243386-012-O-Methyl-5-iodouridine
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MBS58262272'-O-Methyl-5'-O-DMT-5-iodouridine
GTR19214873-015'-O- (4,4'-Dimethoxytrityl) -2'-O-methyl-3'-O-acetyl-5-iodouridine
MBS58262115'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-3'-O-acetyl-5-iodouridine
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