2'-β-C-Ethynyladenosine

• Target:

  Nucleoside Antimetabolite/Analog|||HCV Protease

• Related Pathways:

  DNA Damage/DNA Repair|||Cell Cycle/Checkpoint|||Proteases/Proteasome|||Microbiology/Virology

• Bioactivity:

  2'-?-C-Ethynyladenosine is a synthetic nucleoside analog that functions as a potent inhibitor of hepatitis C virus (HCV) replication by targeting the viral RNA-dependent RNA polymerase, NS5B; it inhibits HCV subgenomic replicon replication and NS5B-catalyzed RNA synthesis with half-maximal inhibitory concentration (IC50) values of 0.3 micromolar and 1.9 micromolar, respectively, and also demonstrates potent inhibitory activity against Leishmania RNA Virus 1 (LRV1) in species such as Leishmania guyanensis (Lgy) and Leishmania braziliensis.

• Smiles:

  C(#C)[C@]1(O)[C@@H](O[C@H](CO)[C@H]1O)N2C=3C(N=C2)=C(N)N=CN3

• Molecular Formula:

  C12H13N5O4

• Molecular Weight:

  291.26

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  640725-76-4