Physalin H

• Target:

  Endogenous Metabolite|||Antifection|||gp120/CD4|||Autophagy|||Hedgehog/Smoothened

• Related Pathways:

  GPCR/G Protein|||Metabolism|||Stem Cells|||Immunology/Inflammation|||Microbiology/Virology|||Autophagy

• Bioactivity:

  Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR induction activity) value of 3.74±0.02. Physalin H shows immunosuppressive effects on T cells both in vitro and in vivo, and the immunosuppressive activity might be attributed to the suppression of T cell activation and proliferation, the modulation of Th1/Th2 cytokine balance and the induction of HO-1 in T cells. Physalin H shows significant in vitro leishmanicidal activities (0.92-19.4 microg/ml) against promastigotes of Leishmania major.Physalin H shows cytotoxic activity against a panel of human and murine cancer cell lines.

• Smiles:

  C[C@]12[C@]34[C@]5([C@@]6(C)[C@@](CO[C@](O3)(C5=O)[C@]7([C@](CC[C@@]4(O)C(=O)O1)([C@]8(C)[C@@](Cl)([C@H](O)C7)CC=CC8=O)[H])[H])(C(=O)O[C@@H]2C6)[H])[H]

• Molecular Formula:

  C28H31ClO10

• Molecular Weight:

  562.99

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  70241-09-7