Physalin B

CAT: 0931-TN2063-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-TN2063-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

23133-56-4

Target

Autophagy, NOD, Apoptosis, Akt, NF-κB, Nrf2, PI3K

Related Pathways

Autophagy, Apoptosis, PI3K/Akt/mTOR signaling, NF-κB, Immunology/Inflammation, Cytoskeletal Signaling

Purity

0.984

Bioactivity

Physalin B is one of the major active compounds from the Solanaceae family of plants and has a wide range of biological activities for the treatment of inflammatory eczema and herpes, among other diseases.Physalin B ameliorates lipopolysaccharide-induced inflammatory response due to acute lung injury by inhibiting NF-κB and NLRP3 through activation of the PI3K/Akt pathway.Physalin B inhibits PDGF-BB-induced VSMC proliferation and migration and phenotypic transformation through activation of the Nrf2 pathway. Physalin B inhibits PDGF-BB-induced VSMC proliferation, migration and phenotypic transformation through activation of the Nrf2 pathway.Physalin B exerts antitumor activity by inhibiting LAP2α-HDAC1-mediated deacetylation of glioma-associated oncogene 1 and hepatic stellate cell activation.

Smiles

[H][C@@]12C(=O)[C@]34O[C@]11[C@@](C)(OC(=O)[C@@]1(O)CC[C@@]1([H])[C@@]3([H])CC=C3CC=CC(=O)[C@]13C)[C@H]1C[C@]2(C)[C@@]([H])(CO4)C(=O)O1

Molecular Formula

C28H30O9

Molecular Weight

510.53

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Physalin B

CID 11613161 has been reported in Witheringia solanacea, Alkekengi officinarum, and other organisms with data available.

CAS Number	23133-56-4
PubChem CID	11613161
IUPAC Name	(1R,2S,5R,8S,9R,17R,18R,21S,24R,26S,27S)-5-hydroxy-2,9,26-trimethyl-3,19,23,28-tetraoxaoctacyclo[16.9.1.118,27.01,5.02,24.08,17.09,14.021,26]nonacosa-11,14-diene-4,10,22,29-tetrone
Molecular Formula	C28H30O9
Molecular Weight	510.5
XLogP	0.8
Topological Polar Surface Area	125
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	0
Heavy Atom Count	37
Formal Charge	0
Complexity	1300

SMILES

C[C@]12C[C@@H]3[C@]4([C@]56[C@H]1C(=O)[C@](O5)([C@@H]7CC=C8CC=CC(=O)[C@@]8([C@H]7CC[C@@]6(C(=O)O4)O)C)OC[C@H]2C(=O)O3)C

InChI

InChI=1S/C28H30O9/c1-23-11-18-25(3)28-19(23)20(30)27(37-28,34-12-16(23)21(31)35-18)15-8-7-13-5-4-6-17(29)24(13,2)14(15)9-10-26(28,33)22(32)36-25/h4,6-7,14-16,18-19,33H,5,8-12H2,1-3H3/t14-,15+,16-,18+,19-,23+,24-,25-,26-,27+,28-/m0/s1

InChIKey

HVTFEHJSUSPQBK-DNJDGUCCSA-N

Chemical Structure

2D Structure

CAS: 23133-56-4

CID: 11613161

Formula: C28H30O9

MW: 510.5

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	510.5
XLogP3	0.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	0
Exact Mass	510.18898253
Monoisotopic Mass	510.18898253
Topological Polar Surface Area	125 Å²
Heavy Atom Count	37
Formal Charge	0
Complexity	1300
Isotope Atom Count	0
Defined Atom Stereocenter Count	11
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
TN4774-01	Physalin A
TN4776	Physalin D
TN4777	Physalin G
TN7372-01	Physalin X
T8716-01	Physalin F
TN4775-01	Physalin C
TN4778	Physalin H
TN1102-01	Physalin L
TN4779-01	Physalin O
TN7667	Desacylsenegasaponin B

Alternative Products

Catalog	Name
TRC-P397900-1MG	Physalin A
VEA84918-01	Physalin O
583133	Physalin F
MBS3612675-01	Physalin L
MBS5786776	Physalin B
MBS5762941	Physalin G
GTR19269491	Physalin C
HY-N9912-01	Physalin D

Physalin B

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