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Physalin A

CAT: 0931-TN4774-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-TN4774-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
23027-91-0
Target
JAK, Autophagy, STAT, mTOR, Apoptosis, p38 MAPK, Akt, NF-κB, PI3K
Related Pathways
NF-κB, Tyrosine Kinase/Adaptors, Autophagy, Angiogenesis, Chromatin/Epigenetic, Stem Cells, MAPK, Cytoskeletal Signaling, PI3K/Akt/mTOR signaling, Apoptosis, JAK/STAT signaling
Purity
0.9971
Bioactivity
Physalin A is an anti-inflammatory compound isolated from P. alkekengi with anti-fibrotic effects, regulating the Nrf2 pathway through ERK and p38 to induce detoxification enzymes. Physalin A blocks the activation of the NF-kappaB signaling pathway. Physalin A reduces mammosphere formation by reducing the expression of the GLI1 gene and the YAP1 gene.
Smiles
C[C@@]12[C@]34[C@]([C@]5(C)C[C@]1(OC(=O)C5=C)[H])(C(=O)[C@](O)(O3)[C@]6([C@](CC[C@]4(O)C(=O)O2)([C@]7(C)C(=C[C@H]6O)CC=CC7=O)[H])[H])[H]
Molecular Formula
C28H30O10
Molecular Weight
526.53
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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