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Morachalcone A

CAT: 0931-TN4580-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-TN4580-01Size:1 mg
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CAS Number
76472-88-3
Target
Tyrosinase, NO Synthase
Related Pathways
Immunology/Inflammation, Proteases/Proteasome
Purity
0.97
Bioactivity
Morachalcone A displays significant tyrosinase inhibitory activity (IC50, 0.013 uM) ; it also exerts strong pancreatic lipase inhibition with IC 50 value of 6.2 uM. Morachalcone A exhibits neuroprotective effects on HT22-immortalized hippocampal cells against glutamate-induced oxidative stress, with EC50 values of 35.5±2.1 uM. It exhibits potent inhibitory activity on nitric oxide production in RAW264.7 LPS-activated mouse macrophage cells with IC50 value of 16.4 microM.
Smiles
C\C(C)=C/Cc1c(O)ccc(C(=O)\C=C\c2ccc(O)cc2O)c1O
Molecular Formula
C20H20O5
Molecular Weight
340.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Morachalcone A

Morachalcone A is a member of chalcones.

CAS Number76472-88-3
PubChem CID9862769
IUPAC Name(E)-1-[2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl]-3-(2,4-dihydroxyphenyl)prop-2-en-1-one
Molecular FormulaC20H20O5
Molecular Weight340.4
XLogP4.7
Topological Polar Surface Area98
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count25
Formal Charge0
Complexity508
SMILES
CC(=CCC1=C(C=CC(=C1O)C(=O)/C=C/C2=C(C=C(C=C2)O)O)O)C
InChI
InChI=1S/C20H20O5/c1-12(2)3-7-15-18(23)10-8-16(20(15)25)17(22)9-5-13-4-6-14(21)11-19(13)24/h3-6,8-11,21,23-25H,7H2,1-2H3/b9-5+
InChIKey
NXBYIJSAISXPKJ-WEVVVXLNSA-N
Chemical Structure
2D Structure
2D structure of Morachalcone A
CAS: 76472-88-3
CID: 9862769
Formula: C20H20O5
MW: 340.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight340.4
XLogP34.7
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass340.13107373
Monoisotopic Mass340.13107373
Topological Polar Surface Area98 Ų
Heavy Atom Count25
Formal Charge0
Complexity508
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-N3246-01Morachalcone A

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