Monomethyl lithospermate

• Target:

  PI3K|||Akt

• Related Pathways:

  Cytoskeletal Signaling|||PI3K/Akt/mTOR signaling

• Bioactivity:

  Monomethyl lithospermate (Lithospermic acid monomethyl ester) has potential antiviral activity, alleviating ischemic stroke injury in vivo in middle cerebral artery occlusion mice by activating PI5K/Akt signaling and protecting oxygen-glucose deprivation/reoxygenation-induced SHSY-3Y cells in vitro. Monomethyl lithospermate could improve the viability of SHSY-5Y cells, inhibit mitochondrial membrane potential (MMOP) collapse, and inhibit cell apoptosis. Monomethyl lithospermate also reduced the level of oxidative stress in the brain tissue of middle artery occlusion (MCAO) rats and improved nerve damage in ischemic stroke (IS) rats.

• Smiles:

  C(OC)(=O)[C@H]1C=2C(O[C@@H]1C3=CC(O)=C(O)C=C3)=C(O)C=CC2/C=C/C(O[C@H](CC4=CC(O)=C(O)C=C4)C(O)=O)=O

• Molecular Formula:

  C28H24O12

• Molecular Weight:

  552.48

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  933054-33-2