4beta-Hydroxywithanolide E

• CAS Number :

  54334-04-2

• Target :

  PPAR|||COX|||PARP|||NF-?B|||HSP

• Related Pathways :

  Cytoskeletal Signaling|||DNA Damage/DNA Repair|||Neuroscience|||Metabolism|||Immunology/Inflammation|||NF-?B|||Chromatin/Epigenetic

• Bioactivity :

  4beta-Hydroxywithanolide E (4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progression and develop into a dietary chemopreventive agent, it affects alternative splicing by modulating splicing factors and histone modifications.4bHWE is a useful natural anti-inflammatory compound to attenuate progression of diabetes and obesity, it decreases inflammatory responses by inhibiting the NF-κB signaling in diabetic mouse adipose tissue, it also can improve impaired glucose tolerance.

• Smiles :

  [H][C@@]12C[C@]3([H])[C@]([H])(CC[C@@]4(C)[C@@]3(O)CC[C@@]4(O)[C@@](C)(O)[C@@]3([H])CC(C)=C(C)C(=O)O3)[C@@]3(C)C(=O)C=C[C@H](O)[C@@]13O2|c:37,t:26|

• Molecular Formula :

  C28H38O8

• Molecular Weight :

  502.604

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C