Products for Research Use Only
RegisterLogin

1-Hydroxy-2,3,5-trimethoxyxanthone

CAT: 0931-TN2534Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-TN2534Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
22804-49-5
Target
COX, Calcium Channel, 5-HT Receptor, IκB/IKK, NOS
Related Pathways
Neuroscience, Metabolism, GPCR/G Protein, Membrane transporter/Ion channel, Immunology/Inflammation, NF-κB
Bioactivity
1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) exhibits vasodilator action through an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by inhibiting Ca (2+) influx via L-type voltage-operated Ca (2+) channels. A minor contribution to HM-1's effects may stem from inhibiting protein kinase C-mediated release of intracellular Ca (2+) stores. At 1 μg/mL, HM-1 effectively inhibits osteoclast differentiation in co-cultures with mouse osteoblastic calvarial and bone marrow cells and protects mice from acute lung injury induced by lipopolysaccharide (LPS), likely by increasing IκB-α protein expression and suppressing inducible nitric oxide synthase and cyclooxygenase-II protein expression.
Smiles
COc1cc2oc3c(OC)cccc3c(=O)c2c(O)c1OC
Molecular Formula
C16H14O6
Molecular Weight
302.28
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Related Products

CatalogName
TN7983-011,2,3-Trimethoxyxanthone
TN59173,6-Dihydroxy-1,2,7-trimethoxyxanthone
T4617-013,8-Dihydroxy-2,4,6-trimethoxyxanthone
TN8741-011-hydroxy-3,5-dimethoxyxanthone
TN28853- (4-Hydroxy-3,5-dimethoxyphenyl) -1,2-propanediol
T29456-015-Hydroxy-2-phenyl-1,3-dioxane, trans-
T29455-015-Hydroxy-2-phenyl-1,3-dioxane, cis-
T29558-01Acetamide, N- (2-hydroxy-3- (2- (2-hydroxy-5-nitrophenyl) diazenyl) -5-methylphenyl) -
TN10017-012-Hydroxy-5-iminoazacyclopent-3-ene
TN28483- (2,4-Dihydroxybenzyl) -5-hydroxy

Alternative Products

CatalogName
3787121-Hydroxy-2,3,5-trimethoxyxanthone
FH146852-011-Hydroxy-3,4,5-trimethoxyxanthone
AB16651-Hydroxy-3,7,8-trimethoxyxanthone
GTR19233441-011,2,3-Trimethoxyxanthone
RLB21079-013,6-Dihydroxy-1,2,7-trimethoxyxanthone
HY-N42923,8-Dihydroxy-2,4,6-trimethoxyxanthone
sc-3080502-Hydroxy-1,3,5-benzenetricarbaldehyde
OR46736-015-Hydroxy-2,1,3-benzothiadiazole
OR3413-015-Hydroxy-2,1,3-benzoxadiazole
OR241105-hydroxy-1,3,5-triazinane-2-thione

Popular Products