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Methylnissolin

CAT: 0931-TN2354-02Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0931-TN2354-02Size:1 mL - 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
73340-41-7
Target
PDGFR, ERK
Related Pathways
Tyrosine Kinase/Adaptors, MAPK, Angiogenesis
Purity
0.9998
Bioactivity
Methylnissolin is a natural product isolated from Astragalus membranaceus that inhibits platelet-derived growth factor (PDGF) -BB-induced cell proliferation with an IC50 of 10 μM. It inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibiting the ERK1/2 MAP kinase cascade. It also inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinases and has antibacterial and anticancer effects.
Smiles
[H][C@@]12COc3cc(O)ccc3[C@]1([H])Oc1c2ccc(OC)c1OC
Molecular Formula
C17H16O5
Molecular Weight
300.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

(6aR,11aR)-3-Hydroxy-9,10-dimethoxypterocarpan

Astrapterocarpan is a member of pterocarpans.

CAS Number73340-41-7
PubChem CID14077830
IUPAC Name(6aR,11aR)-9,10-dimethoxy-6a,11a-dihydro-6H-[1]benzofuro[3,2-c]chromen-3-ol
Molecular FormulaC17H16O5
Molecular Weight300.30
XLogP2.6
Topological Polar Surface Area57.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Heavy Atom Count22
Formal Charge0
Complexity403
SMILES
COC1=C(C2=C(C=C1)[C@@H]3COC4=C([C@@H]3O2)C=CC(=C4)O)OC
InChI
InChI=1S/C17H16O5/c1-19-13-6-5-10-12-8-21-14-7-9(18)3-4-11(14)15(12)22-16(10)17(13)20-2/h3-7,12,15,18H,8H2,1-2H3/t12-,15-/m0/s1
InChIKey
UOVGCLXUTLXAEC-WFASDCNBSA-N
Chemical Structure
2D Structure
2D structure of (6aR,11aR)-3-Hydroxy-9,10-dimethoxypterocarpan
CAS: 73340-41-7
CID: 14077830
Formula: C17H16O5
MW: 300.30
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight300.30
XLogP32.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass300.09977361
Monoisotopic Mass300.09977361
Topological Polar Surface Area57.2 Ų
Heavy Atom Count22
Formal Charge0
Complexity403
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA6449-5Methylnissolin
A24198-1Methylnissolin (Astrapterocarpan) 1mg
A24198-5Methylnissolin (Astrapterocarpan) 5mg
A24198-50Methylnissolin (Astrapterocarpan) 50mg
A24198-10Methylnissolin (Astrapterocarpan) 10mg
MBS3610488-01Methylnissolin-3-O-glucoside
GTR19157526-01Methylnissolin-3-O-glucoside?
HY-N2473RMethylnissolin-3-O-glucoside (Standard)

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