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Methylnissolin

CAT: 0931-TN2354-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-TN2354-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
73340-41-7
Target
PDGFR, ERK
Related Pathways
Tyrosine Kinase/Adaptors, MAPK, Angiogenesis
Purity
0.9998
Bioactivity
Methylnissolin is a natural product isolated from Astragalus membranaceus that inhibits platelet-derived growth factor (PDGF) -BB-induced cell proliferation with an IC50 of 10 μM. It inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibiting the ERK1/2 MAP kinase cascade. It also inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinases and has antibacterial and anticancer effects.
Smiles
[H][C@@]12COc3cc(O)ccc3[C@]1([H])Oc1c2ccc(OC)c1OC
Molecular Formula
C17H16O5
Molecular Weight
300.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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