NCT-58

• Target :

  Apoptosis|||HSP

• Related Pathways :

  Apoptosis|||Cytoskeletal Signaling|||Metabolism

• Purity :

  0.996

• Bioactivity :

  NCT-58 is a potent C-terminal HSP90 inhibitor. NCT-58 does not induce the heat shock response (HSR) . NCT-58 elicits anti-tumor activity via the simultaneous downregulation of HER family members as well as inhibition of Akt phosphorylation. NCT-58 kills Trastuzumab-resistant breast cancer stem-like cells. NCT-58 induces apoptosis in HER2-positive breast cancer cells.

• Smiles :

  COc1cc(NC(=O)c2ccc3OC(C)(C)C=Cc3c2OC)ccc1OCCC1CCCCN1

• Molecular Formula :

  C27H34N2O5

• Molecular Weight :

  466.57

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2411429-33-7