DS-1205

• Target:

  TAM Receptor|||c-Met/HGFR|||Trk receptor

• Related Pathways:

  Tyrosine Kinase/Adaptors

• Purity:

  0.9975

• Bioactivity:

  DS-1205 is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205 also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, respectively. DS-1205 can inhibit cell migration in vitro and tumor growth in vivo[1].

• Smiles:

  COc1cc(ccc1OC[C@H]1COCCO1)-c1cnc(N)c(c1)-c1ccc(NC(=O)c2cn(CC3CCOCC3)cc(-c3ccc(C)cn3)c2=O)cc1F

• Molecular Formula:

  C41H42FN5O7

• Molecular Weight:

  735.8

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1855860-24-0