DS-1205

CAT: 0931-T9123-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T9123-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1855860-24-0
Target
TAM Receptor|||c-Met/HGFR|||Trk receptor
Related Pathways
Tyrosine Kinase/Adaptors
Purity
0.9975
Bioactivity
DS-1205 is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205 also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, respectively. DS-1205 can inhibit cell migration in vitro and tumor growth in vivo[1].
Smiles
COc1cc(ccc1OC[C@H]1COCCO1)-c1cnc(N)c(c1)-c1ccc(NC(=O)c2cn(CC3CCOCC3)cc(-c3ccc(C)cn3)c2=O)cc1F
Molecular Formula
C41H42FN5O7
Molecular Weight
735.8
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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