WYE-687

CAT: 0931-T6732-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0931-T6732-01Size:100 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1062161-90-3
Target
Src|||PI3K|||p38 MAPK|||mTOR
Related Pathways
MAPK|||Angiogenesis|||PI3K/Akt/mTOR signaling|||Tyrosine Kinase/Adaptors
Purity
0.9993
Bioactivity
WYE-687 is an ATP-competitive and selective inhibitor of mTOR with an IC50 of 7 nM; it blocks mTORC1/pS6K (T389) and mTORC2/P-AKT (S473) without affecting P-AKT (T308) . Its selectivity for mTOR is greater than PI3K? (>100-fold) and PI3K? (>500-fold) .
Smiles
COC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4cccnc4)CC3)c2n1
Molecular Formula
C28H32N8O3
Molecular Weight
528.61
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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