WYE-687

• Target:

  Src|||PI3K|||p38 MAPK|||mTOR

• Related Pathways:

  MAPK|||Angiogenesis|||PI3K/Akt/mTOR signaling|||Tyrosine Kinase/Adaptors

• Purity:

  0.9993

• Bioactivity:

  WYE-687 is an ATP-competitive and selective inhibitor of mTOR with an IC50 of 7 nM; it blocks mTORC1/pS6K (T389) and mTORC2/P-AKT (S473) without affecting P-AKT (T308) . Its selectivity for mTOR is greater than PI3K? (>100-fold) and PI3K? (>500-fold) .

• Smiles:

  COC (=O) Nc1ccc (cc1) -c1nc (N2CCOCC2) c2cnn (C3CCN (Cc4cccnc4) CC3) c2n1

• Molecular Formula:

  C28H32N8O3

• Molecular Weight:

  528.61

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1062161-90-3