WYE-687

• Target :

  Src|||PI3K|||p38 MAPK|||mTOR

• Related Pathways :

  MAPK|||Angiogenesis|||PI3K/Akt/mTOR signaling|||Tyrosine Kinase/Adaptors

• Purity :

  0.9993

• Bioactivity :

  WYE-687 is an ATP-competitive and selective inhibitor of mTOR with an IC50 of 7 nM; it blocks mTORC1/pS6K (T389) and mTORC2/P-AKT (S473) without affecting P-AKT (T308) . Its selectivity for mTOR is greater than PI3K? (>100-fold) and PI3K? (>500-fold) .

• Smiles :

  COC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4cccnc4)CC3)c2n1

• Molecular Formula :

  C28H32N8O3

• Molecular Weight :

  528.61

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1062161-90-3