Fludarabine Phosphate

• CAS Number :

  75607-67-9

• Target :

  DNA/RNA Synthesis|||Apoptosis|||Nucleoside Antimetabolite/Analog

• Related Pathways :

  Apoptosis|||Cell Cycle/Checkpoint|||DNA Damage/DNA Repair

• Purity :

  >99.99%

• Bioactivity :

  Fludarabine Phosphate (NSC 312887 Phosphate) is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase, and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth.

• Smiles :

  Nc1nc(F)nc2n(cnc12)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O

• Molecular Formula :

  C10H13FN5O7P

• Molecular Weight :

  365.21

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C