Fludarabine Phosphate

• Target:

  DNA/RNA Synthesis|||Apoptosis|||Nucleoside Antimetabolite/Analog

• Related Pathways:

  Apoptosis|||Cell Cycle/Checkpoint|||DNA Damage/DNA Repair

• Purity:

  >99.99%

• Bioactivity:

  Fludarabine Phosphate (NSC 312887 Phosphate) is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase, and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth.

• Smiles:

  Nc1nc (F) nc2n (cnc12) [C@@H]1O[C@H] (COP (O) (O) =O) [C@@H] (O) [C@@H]1O

• Molecular Formula:

  C10H13FN5O7P

• Molecular Weight:

  365.21

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  75607-67-9