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Fludarabine Phosphate

CAT: 0931-T6501-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T6501-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
75607-67-9
Target
DNA/RNA Synthesis, Apoptosis, Nucleoside Antimetabolite/Analog
Related Pathways
Apoptosis, Cell Cycle/Checkpoint, DNA Damage/DNA Repair
Purity
>99.99%
Bioactivity
Fludarabine Phosphate (NSC 312887 Phosphate) is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase, and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth.
Smiles
Nc1nc(F)nc2n(cnc12)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O
Molecular Formula
C10H13FN5O7P
Molecular Weight
365.21
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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