CYC-116

CAT: 0931-MF-0049714-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0049714-01Size:5 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
693228-63-6
Target
VEGFR|||FLT|||Aurora Kinase|||S6 Kinase|||CDK
Related Pathways
MAPK|||Chromatin/Epigenetic|||Tyrosine Kinase/Adaptors|||PI3K/Akt/mTOR signaling|||Angiogenesis|||Cell Cycle/Checkpoint
Purity
0.9759
Bioactivity
CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3?/?, CK2, Plk1 and SAPK2A. Phase 1.
Smiles
Cc1nc(N)sc1-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Molecular Formula
C18H20N6OS
Molecular Weight
368.46
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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