CYC-116

• Target:

  VEGFR|||FLT|||Aurora Kinase|||S6 Kinase|||CDK

• Related Pathways:

  MAPK|||Chromatin/Epigenetic|||Tyrosine Kinase/Adaptors|||PI3K/Akt/mTOR signaling|||Angiogenesis|||Cell Cycle/Checkpoint

• Purity:

  0.9759

• Bioactivity:

  CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3?/?, CK2, Plk1 and SAPK2A. Phase 1.

• Smiles:

  Cc1nc(N)sc1-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1

• Molecular Formula:

  C18H20N6OS

• Molecular Weight:

  368.46

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  693228-63-6