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Clevudine

CAT: 0931-T6446-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T6446-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
163252-36-6
Target
Virus Protease, DNA/RNA Synthesis, HBV
Related Pathways
DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Microbiology/Virology
Purity
0.9998
Bioactivity
Clevudine (Levovir) is a synthetic pyrimidine analogue with activity against hepatitis B virus (HBV) . Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The triphosphate metabolite competes with thymidine for incorporation into viral DNA, thereby causing DNA chain termination and inhibiting the function of HBV DNA polymerase (reverse transcriptase) . Clevudine has a long half-life and shows significant reduction of covalently closed circular DNA (cccDNA), therefore the patient is less likely to have a relapse after treatment is discontinued.
Smiles
Cc1cn([C@H]2O[C@@H](CO)[C@H](O)[C@H]2F)c(=O)[nH]c1=O
Molecular Formula
C10H13FN2O5
Molecular Weight
260.22
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Clevudine

Clevudine is a pyrimidine 2'-deoxyribonucleoside.

CAS Number163252-36-6
PubChem CID73115
IUPAC Name1-[(2S,3R,4S,5S)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
Molecular FormulaC10H13FN2O5
Molecular Weight260.22
XLogP-0.9
Topological Polar Surface Area99.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Heavy Atom Count18
Formal Charge0
Complexity413
SMILES
CC1=CN(C(=O)NC1=O)[C@@H]2[C@@H]([C@H]([C@@H](O2)CO)O)F
InChI
InChI=1S/C10H13FN2O5/c1-4-2-13(10(17)12-8(4)16)9-6(11)7(15)5(3-14)18-9/h2,5-7,9,14-15H,3H2,1H3,(H,12,16,17)/t5-,6+,7-,9-/m0/s1
InChIKey
GBBJCSTXCAQSSJ-XQXXSGGOSA-N
Chemical Structure
2D Structure
2D structure of Clevudine
CAS: 163252-36-6
CID: 73115
Formula: C10H13FN2O5
MW: 260.22
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight260.22
XLogP3-0.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Exact Mass260.08084968
Monoisotopic Mass260.08084968
Topological Polar Surface Area99.1 Ų
Heavy Atom Count18
Formal Charge0
Complexity413
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
329107Clevudine
HY-125719Clevudine triphosphate

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