Clevudine

• CAS Number :

  163252-36-6

• Target :

  Virus Protease|||DNA/RNA Synthesis|||HBV

• Related Pathways :

  DNA Damage/DNA Repair|||Cell Cycle/Checkpoint|||Microbiology/Virology

• Purity :

  0.9998

• Bioactivity :

  Clevudine (Levovir) is a synthetic pyrimidine analogue with activity against hepatitis B virus (HBV) . Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The triphosphate metabolite competes with thymidine for incorporation into viral DNA, thereby causing DNA chain termination and inhibiting the function of HBV DNA polymerase (reverse transcriptase) . Clevudine has a long half-life and shows significant reduction of covalently closed circular DNA (cccDNA), therefore the patient is less likely to have a relapse after treatment is discontinued.

• Smiles :

  Cc1cn([C@H]2O[C@@H](CO)[C@H](O)[C@H]2F)c(=O)[nH]c1=O

• Molecular Formula :

  C10H13FN2O5

• Molecular Weight :

  260.22

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C