Clevudine

CAT: 0223-11-076Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0223-11-076Size:50 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Clevudine is a synthetic pyrimidine nucleoside analog antiviral agent with activity against hepatitis B virus (HBV) and Epstein-Barr virus (EBV) . Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The triphosphate metabolite competes with thymidine for incorporation into viral DNA, thereby causing DNA chain termination and inhibiting the function of HBV DNA polymerase and reverse transcriptase, consequently blocking the viral replication. It also blocks the DNA supply of the virus into the nucleus, reducing the amount of cccDNA by 20-100 times. Potentially useful for the treatment of the SARS-CoV-2 (COVID-19) infection, acting as a potent inhibitor of the RdRp protein.

CAS Number

163252-36-6

Type

Chemical

Purity

Greater than or equal to 98% (HPLC)

Shipping Conditions

Room Temp

Storage Conditions

Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.

Calculated Molecular Weight

260.2

Other Product Names

Levovir; L-FMAU; 2'-Fluoro-5-methyl-β-L-arabinofuranosyl-uracil

Physical Properties

Lyophilized

Alternative Products

Catalog	Name
329107	Clevudine
HY-125719	Clevudine triphosphate

Clevudine

Alternative Products

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